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Proposed Weight-Adjusted Oral Challenge Protocol for Suspected Cross-Reactive Hypersensitivity Reactions to NSAID in Children Up to 40 kg
| Challenge Medication | Challenge Dose (mg/kg) | Advance Dose Schedule | Interval between Challenges (h) | Maximal Dose (mg/kg) | Range of Reaction Dose (mg/kg) | Usual Time to Reaction (h) |
|---|---|---|---|---|---|---|
| Aspirin | 2.5 | Repeat same | 1 | 10 | 2.5--10 | 1--4 |
| Ibuprofen | 2.5 | Repeat same | 1 | 10 | 5--10 | 2--4 |
| Paracetamol | 5 | Repeat same | 1 | 20 | 10--20 | 2--4 |
