Effects of testosterone administration on whole body and regional fat mass in adult, orchidectomized mice. (A) Effect of testosterone treatment on percent body fat in adult, orchidectomized mice. C57BL/6 mice were orchidectomized and assigned to one of two groups. Group A: orchidectomized (n = 6); group B: orchidectomized-T, treated with silastic implants containing testosterone (n = 5). Treatment duration was 2 weeks. Fat mass was determined using NMR. *P vs. orchidectomized controls <0.05. (B) Subcutaneous, perirenal, and epididymal fat depot weights in orchidectomized controls (clear bars) and testosterone-treated (shaded bars) orchidectomized mice. The magnitude of difference between the controls and testosterone-treated orchidectomized mice was greater in epididymal fat than in subcutaneous (SC) and perirenal fat. SC, subcutaneous; *P vs. orchidectomized controls <0.05.