Table V.
Summary of the major areas of activation
| Comparison | Direction of effect | Cingulate cortical regions | Other frontal regions | Other regions identified |
|---|---|---|---|---|
| Resting studies | Decreased in patients | Pregenual | Bilateral MFG | Insula |
| Dorsal | STG | |||
| Increased in patients | Bilateral SFG | Thalamus | ||
| L medial and inferior FG | Caudate | |||
| R MFG | Anterior cerebellum | |||
| Treatment studies | Increased with treatment | Dorsal | Bilateral MFG | Putamen |
| Posterior | L IFG | Midbrain | ||
| Parietal and precentral | ||||
| Decreased with treatment | Pregenual | L MFG and SFG | Insula | |
| Subgenual | R medial and inferior | Putamen | ||
| Hippocampus/ parahippocampal gyrus | ||||
| Induction of positive affect | Decreased in patients | Pregenual | L orbitofrontal | Medial and lateral temporal |
| Posterior | Posterior cerebellum | |||
| Increased in patients | Subgenual | R medial | Lingual gyrus | |
| Posterior | Bilateral inferior | Precentral gyrus | ||
| Lateral (R > L) | ||||
| Induction of negative affect | Decreased in patients | Pregenual/dorsal | Bilateral MFG | Insula |
| Posterior | R IFG | Superior temporal gyrus | ||
| R SFG | Anterior and posterior cerebellum | |||
| Increased in patients | Posterior | Bilateral IFG | Lateral temporal cortex | |
| R MFG | Parietal cortex | |||
| Amygdala, putamen | ||||
| Posterior cerebellum |