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A. Two-step conversion of arachidonic acid (AA) to prostaglandin H2 (PGH2) by the cyclooxygenase and peroxidase active sites of cyclooxygenase (COX). PPIX: Protoporphyrin IX. DH2 (or DH): reduced co-substrate. D (or D•): oxidized co-substrate. B. The oxygenation of AA to a primary hydroperoxyeicosatetraenoic acid (HPETE) as exemplified by 15-LOX-1. C. General mechanism of LOX catalysis, where the amino acid sidechain ligands on the non-heme iron are omitted for clarity.
