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. Author manuscript; available in PMC: 2010 Dec 21.
Published in final edited form as: Org Biomol Chem. 2009 Oct 20;7(24):5103–5112. doi: 10.1039/b912528k

Fig. 4.

Fig. 4

oCOX-1 inhibition by acetaminophen and its pyridine and pyrimidine analogs. oCOX-1 activity is expressed relative to the control where no inhibitor was added (specific activity of 200 mol AA per mol enzyme per min). Each data point represents the mean ± S.E.M of four to six values. IC50 values (μM): 1 (×), 250; 2 (△), 399; 3 (▲), 761; 5a (□) 22.0; 5b (■) 20.1; 6a (○) 18.4; 6b (●) 10.0.