TABLE 3. Meta-Analysis of Gray Matter Changes in First-Episode Schizophrenia^a.

Coordinates
x	y	z	Hemisphere	Label	Volume (mm3)	Maximum ALE Value
First-episode schizophrenia < comparison subjects
−18	−2	−22	Left	Uncus/amygdala	2,760	0.018
−40	6	0	Left	Insula	1,552	0.010
10	10	12	Right	Caudate	1,392	0.012
−28	30	−6	Left	Inferior frontal gyrus (Brodmann’s area 47)	736	0.009
20	−4	−22	Right	Uncus/amygdala	688	0.012
34	4	8	Right	Insula	680	0.008
−60	−18	22	Left	Parietal lobe, postcentral gyrus	640	0.012
				(Brodmann’s area 40)
−12	6	12	Left	Caudate	528	0.010
8	16	38	Right	Cingulate gyrus (Brodmann’s area 32)	464	0.007
26	10	−18	Right	Inferior frontal gyrus (Brodmann’s area 47)	360	0.007
−36	42	4	Left	Inferior frontal gyrus	352	0.007
−4	−66	−26	Left	Cerebellum, anterior lobe, pyramis	320	0.008
58	−6	30	Right	Precentral gyrus (Brodmann’s area 6)	312	0.007
2	−18	10	Right	Thalamus, medial dorsal nucleus	312	0.007
30	−42	−32	Right	Cerebellar tonsil	296	0.007
−6	−50	−20	Left	Cerebellum, anterior lobe, fastigium	280	0.007
−44	−12	12	Left	Insula (Brodmann’s area 13)	240	0.007
First-episode schizophrenia > comparison subjects
12	48	42	Right	Superior frontal gyrus (Brodmann’s area 8)	1,648	0.008
−22	0	12	Left	Putamen	1,592	0.008
22	−90	−14	Right	Occipital lobe, fusiform gyrus	1,120	0.009
				(Brodmann’s area 18)
−12	46	44	Left	Superior frontal gyrus (Brodmann’s area 8)	1,080	0.008
−38	38	34	Left	Middle frontal gyrus (Brodmann’s area 9)	912	0.007
−10	28	56	Left	Superior frontal gyrus (Brodmann’s area 6)	376	0.006
−14	−26	58	Left	Frontal lobe, precentral gyrus	360	0.006
				(Brodmann’s area 4)
−16	−96	−6	Left	Occipital lobe, lingual gyrus	360	0.006
				(Brodmann’s area 17)
14	−26	62	Right	Frontal lobe, precentral gyrus	320	0.006
				(Brodmann’s area 4)
52	−40	40	Right	Inferior parietal lobule (Brodmann’s area 40)	312	0.006
−16	−24	−20	Left	Cerebellum, anterior lobe, culmen	312	0.006
36	−18	−2	Right	Insula	288	0.007
−36	−52	12	Left	Superior temporal gyrus	280	0.007
				(Brodmann’s area 22)

^aSignificant clusters with a false discovery rate set at p<0.05 and a cluster extent threshold of 100 voxels.