. Author manuscript; available in PMC: 2011 Feb 7.

Published in final edited form as: Dalton Trans. 2009 Dec 23;39(5):1159–1170. doi: 10.1039/b922209j

Table 2.

Biocarriers and their metal cargoes

Biocarrier	Metal Cargo	Comment	Reference
Peptides
RGD/NGR	platinum	integrin substrates	95
PKKKRKV	cobalt, technetium/rhenium	SV40 large tumor antigen NLS	109–111, 113
GRKKRRQRRRAP	zinc, technetium/rhenium	HIV-1 TAT peptide NLS/CPP	106, 115–117
rrrrrrrr	rhodium, ruthenium	synthetic NLS	63, 108
YGGFL	cobalt	enkephalin NLS	112
RKRKRK	gadolinium	acute lymphatic leukemia-1 NLS	114
*B Vitamins*
B₁₂	platinum	endocytosis and metabolism in lysosomes releases Pt	118
*Carbohydrates*
dextran	platinum	branched galactose clusters target cell surface receptors	119–121
*Hormones*
LH-RH	platinum	luteinizing hormone-releasing hormone peptide analogues	122
1,7-β-estradiol	platinum	primary substrate for nuclear estrogen receptor	123–126
*Synthetics*
polymeric micelles	platinum	28 nm micelles from poly(ethylene glycol)-poly(glutamic acid)	127, 128
single-walled carbon nanotubes	platinum	clathrin-mediated endocytosis	129
silica-encased coordination polymers	platinum	degradable shell provides controlled release	130
poly(ethylene glycol)	platinum	macromolecular PEG complexes, some conjugated to albumin	131