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. Author manuscript; available in PMC: 2010 May 20.
Published in final edited form as: Nature. 2009 Jun 18;459(7249):931–939. doi: 10.1038/nature08157

Fig. 2. Schematic diagram of the influenza viral life cycle.

Fig. 2

Following receptor-mediated endocytosis, the viral ribonucleoprotein (vRNP) complexes are released into the cytoplasm and subsequently transported to the nucleus, where replication and transcription take place. mRNAs are exported to the cytoplasm for translation. Early viral proteins, i.e., those required for replication and transcription, are transported back to the nucleus. Late in the infection cycle, the M1 and NS2(=NEP) proteins facilitate the nuclear export of newly synthesized vRNPs. PB1-F2 associates with mitochondria. The assembly and budding of progeny virions occurs at the plasma membrane.