Table 1. MWU test significant regions.
| region | offset | p-value | compare | p-value with mask | recomb | telo | ||||||
| ctl | sea | 500 | 1kb | 5kb | 10kb | 5kbHi | avg | male | ||||
| harseq1* | +1.25 | 0.03562 | 0 | 3 | 0.03562 | 0.07069 | 0.29830 | 0.72170 | 0.29830 | 0.00 | 0.00 | 0 |
| harseq18 | +3.00 | 0.02016 | 0 | 2 | 0.08212 | 0.11110 | 0.10930 | 0.19430 | 0.10930 | 1.70 | 1.39 | 19 |
| harseq20 | +1.09 | 0.01450 | 0 | 2 | 0.00892 | 0.01128 | 0.00861 | 0.01574 | 0.18860 | 1.21 | 1.56 | 6 |
| harseq21 | +2.00 | 0.00090 | 0 | 0 | 0.00090 | 0.00090 | 0.00086 | 0.00138 | 0.00510 | 3.43 | 4.29 | 24 |
| harseq25 | +1.65 | 0.00627 | 0 | 1 | 0.00553 | 0.00826 | 0.00694 | 0.01436 | 0.04611 | 1.81 | 0.39 | 2 |
| harseq27 | +1.16 | 0.01303 | 0 | 2 | 0.01496 | 0.01496 | 0.01932 | 0.12340 | 0.06593 | 1.99 | 1.84 | 2 |
| harseq32 | +0.22 | 0.02369 | 0 | 2 | 0.03274 | 0.03140 | 0.03333 | 0.01323 | 0.15330 | 2.04 | 1.94 | 6 |
| harseq34 | +1.65 | 0.00014 | 0 | 0 | 0.00026 | 0.00030 | 0.00258 | 0.00167 | 0.00258 | 1.42 | 0.00 | 3 |
| harseq35 | +1.00 | 0.04483 | 0 | 3 | 0.04483 | 0.03461 | 0.00175 | 0.01625 | 0.46510 | 2.22 | 1.71 | 4 |
| harseq43 | +1.00 | 0.01237 | 0 | 2 | 0.01237 | 0.00721 | 0.01772 | 0.05556 | 0.08562 | 0.28 | 0.14 | 15 |
| harseq46 | +1.10 | 0.02302 | 0 | 2 | 0.01439 | 0.02300 | 0.00568 | 0.00189 | 0.34770 | 0.37 | 0.44 | 15 |
Target regions with most significant p-values for Mann-Whitney U test distinguishing the frequency spectra of weak-to-strong (W2S) from strong-to-weak (S2W) mutations. Starred regions are also significant in the MK test (Table 2). offset: the estimated offset of the two spectra, normalized to 22 chromosomal samples, with positive values indicating W2S mutations shifted to higher derived allele frequencies. compare: the number of regions in 13 ctlreg50-62 (ctl) or 62 Seattle SNPs (sea) genic regions with a more significant p-value and positive W2S offset. p-value with mask columns are the p-values derived by omitting all segregating sites at the indicated number of bases from the center of the target region. The 5kbHi column gives the highest (least significant) p-value obtained by omitting all segregating sites in a set of overlapping 5kb windows centered at each 2.5kb in the target region. recomb: sex-averaged and male recombination rates from deCODE 1Mb regions. telo: distance of the region from the closer telomere measured in number of karyotype bands, where 0 is the telomeric band.