Table 2. Ingenuity analysis of microRNAs significantly downregulated with age.
| miR-103/107 | miR-128 | miR-130a | miR-155 | |
| Diseases and Disorders | Cardiovascular disease | Genetic disorder | Cancer | Hematological Disease |
| Genetic Disorder | Neurological Disease | Cardiovascular disease | Cancer | |
| Molecular and | Gene Expression | Gene expression | Cell death | Gene Expression |
| Cellular Functions | Cellular Movement | Amino Acid Metabolism | Cellular Movement | Cellular Development |
| Physiological Systems | Nervous System Development and Function | Organismal Development | Organismal Development | Organismal Development |
| Behavior | Organ Development | Organ Development | Hematological System Development and Function | |
| Canonical Pathways | Ran signaling | Molecular Mechanisms of Cancer | Pantothenate and CoA Biosynthesis | T cell Receptor Signaling |
| Wnt/β-catenin Signaling | PPARa/RXR Activation | Human Stem Cell Pluripotency | Prolactin Signaling |
The predicted targets (from Targetscan) were compiled for each respective miRNA and were examined using Ingenuity software. The top two pathways for each parameter are listed.