Figure 3. AAV2-mediated semaphorin 6a overexpression improves recovery over time as measured by Rotarod performance.

Rats were placed on an accelerating Rotarod cylinder, and the time the animals remained on the Rotarod was measured. From day 6 onward rats were trained for a total of 10 days, with 2 days break in between, in an accelerated rotarod training paradigm. Every training day the rats received 10 training sessions. Animals that had received the Sema6a AAV2 virus (blue line) performed significantly better over time than animals that had received empty virus (red line) (repeated measures ANOVA, p<0.05). Post hoc tests revealed significant differences between groups from day 14 onward (p<0.05).