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. 2010 May 20;5(5):e10750. doi: 10.1371/journal.pone.0010750

Table 2. Ki and IC50 values of GCase inhibitors for Vela and Imig.

Inhibitor Vela Imig p value
Deoxynojirimycin (µM)* 23.4 27.4 0.8343
C4-Deoxynojirimycin (µM) 92.8 93.3 0.9692
C9-Deoxynojirimycin (nM) 88.1 66.9 0.8838
C12-Deoxynojirimycin (nM) 9.97 14.7 0.6957
Castanospermine (µM) 2.57 2.28 0.9972
Isofagomine (nM) 30.7 28.8 0.904
Conduritol B epoxide(µM)[IC50] 99.76 146.2 0.8775

*Ki values for all, except Conduritol B epoxide. Equal amounts of Vela or Imig protein (8 pmol) were used. SE in all measurements was ≤20%.