Table 2. Ki and IC50 values of GCase inhibitors for Vela and Imig.
Inhibitor | Vela | Imig | p value |
Deoxynojirimycin (µM)* | 23.4 | 27.4 | 0.8343 |
C4-Deoxynojirimycin (µM) | 92.8 | 93.3 | 0.9692 |
C9-Deoxynojirimycin (nM) | 88.1 | 66.9 | 0.8838 |
C12-Deoxynojirimycin (nM) | 9.97 | 14.7 | 0.6957 |
Castanospermine (µM) | 2.57 | 2.28 | 0.9972 |
Isofagomine (nM) | 30.7 | 28.8 | 0.904 |
Conduritol B epoxide(µM)[IC50] | 99.76 | 146.2 | 0.8775 |
*Ki values for all, except Conduritol B epoxide. Equal amounts of Vela or Imig protein (8 pmol) were used. SE in all measurements was ≤20%.