Table 2. The association between week-8 culture positivity and M. tuberculosis lineage, adjusted for clinical risk factors from the parent study.

Characteristic	Positive week-8 culture[n (row %)]	Univariate Analysis		Multivariate Analysis
		p-value	OR (95% CI)	p-value	OR (95% CI)
Moxifloxacin (n = 152)	56 (37)	0.19	0.74 (0.47–1.17)	0.23	0.73 (0.43–1.22)
Assignment stratum
Non-African/non-cavitary (n = 32)	2 (6.3)		1.00 (ref)		1.00 (ref)
Non-African/cavitary (n = 82)	27 (33)	<0.01	7.36 (1.64–33.1)	0.02	5.93 (1.25–28.1)
African/non-cavitary (n = 47)	21 (45)	<0.01	12.1 (2.59–56.6)	0.01	7.61 (1.43–40.5)
African/cavitary (n = 145)	74 (51)	<0.01	15.6 (3.60–67.8)	<0.01	9.86 (1.99–48.9)
Age at enrollment (per year) *	33 (12)	0.95	1.00 (0.98–1.02)	0.06	1.03 (1.00–1.06)
High bacillary burden on baseline sputum smear (n = 205) *	100 (49)	<0.01	3.06 (1.79–5.21)	0.03	2.02 (1.09–3.76)
Days to detection in liquid culture system for baseline specimen *	7.1 (4.8)	<0.01	0.92 (0.87–0.96)	0.02	0.94 (0.90–0.99)
Lineage
Euro-American – other than 724 (n = 145)	46 (32)		1.00 (ref)		1.00 (ref)
Euro-American – 724 (n = 101)	53 (52)	<0.01	2.38 (1.41–4.01)	0.12	1.70 (0.88–3.30)
East-African-Indian (n = 26)	11 (42)	0.29	1.58 (0.67–3.70)	0.91	0.95 (0.35–2.54)
East Asian (n = 22)	13 (59)	0.02	3.11 (1.24–7.79)	0.30	1.79 (0.60–5.37)
Indo-Oceanic (n = 11)	1 (9.1)	0.15	0.22 (0.03–1.73)	0.27	0.29 (0.03–2.58)

*Mean and standard deviation reported for continuous data.