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. 2010 May 21;5(5):e10760. doi: 10.1371/journal.pone.0010760

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) Locations of 17 amino acids mutated in SCD patients are indicated by arrows. Taller bars in the graph below the alignment indicate greater conservation. (B) Regions of alignment encompassing human SCD mutations: A97, D112, V122, L188, are shown. The position of the human protein in the alignment is indicated on the left (box). (C) Evolutionary relationships based upon UBIAD1 homology.