Table 1.
Breakthroughs in characterizing the functional significance of RLIP76
| Findings/properties of RLIP76 | References |
|---|---|
| Demonstration of GTPase activity of RLIP76 | Jullien-Flores V et al [12] |
| Cloning, purification and reconstitution of RLIP76 in artificial liposomes | Awasthi S et al [13,14] |
| RLIP76 transports GS-Es and DOX in an ATP-dependent manner | Awasthi S et al [13,14] |
| Identification of ATP binding sequences | Awasthi S et al [14] |
| RLIP76 as a GS-Es and DOX transporter in red blood cells | Sharma R et al [39] |
| Induction of RLIP76 and hGST5.8 as an early stress response | Cheng JZ et al [5] |
| RLIP76 mediated transport of GS-HNE and DNP-SG | Singhal SS et al [51] |
| RLIP76 represents the major DOX transporter in lung cancer | Awasthi S et al [35] |
| RLIP76, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis | Rosse C et al [27] |
| RLIP76 transports leukotriene C4 in cancer cells | Sharma R et al [3] |
| Identification of membrane anchoring domains of RLIP76 | Yadav S et al [45] |
| Transport of vinorelbine and role of drug-resistance in NSCLC | Stuckler D et al [32] |
| POB-1 over-expression inhibits transport function of RLIP76 | Yadav S et al [29] |
| Regression of B16 mouse melanoma model by RLIP76 depletion | Singhal SS et al [8] |
| RLIP76 mediates adhesion dependent Rac activation and cell migration | Goldfinger LE et al [44] |
| RLIP76 is required for mitogenic and drug-resistance mediated effects of PKC α | Singhal SS et al [41] |
| Regression of lung and colon cancer xenografts upon RLIP76 depletion | Singhal SS et al [9] |
| Mass spectroscopic phospho-protein mapping of RLIP76 | Herlevsen MC et al [52] |
| Role of antibodies to C-terminal of RLIP76 in immune mediated vascular diseases and atherosclerosis | Margutti P et al [53] |
| Polymorphisms of RLIP76 causes differential drug responses in Epilepsy | Leschziner GD et al [54] |
| Protective effect of RLIP76 against radiation poisoning | Singhal J et al [7] |
| RLIP76 depletion causes regression of prostate cancer xenografts | Singhal SS et al [11] |
| Inhibition of transport function of RLIP76 by Cdc2 | Singhal SS et al [28] |
| Role of RLIP76 in kidney cancer therapy | Singhal SS et al [10,34] |
| RLIP76 transports sunitinib and sorafenib | Singhal SS et al [34] |