Table II.
Effect of RLIP76 inhibition and/or depletion on tumor xenografts
| Cancer type | Estimated deaths in US in 2009 [55] | Cell types used for cancer Xenograft | RLIP76 siRNA | RLIP76 antisense | RLIP76 antibody |
|---|---|---|---|---|---|
| Melanoma [8] | 5,500 male 3,100 female |
B16 mouse melanoma | + | + | + |
| Lung cancer [9] | 88,900 male 70,000 female |
H358 NSCLC H520 NSCLC |
ND | + | + |
| Colon cancer [9] | 5,240 male 4,680 female |
SW480 | ND | + | + |
| Prostate cancer [11] | 27,360 male | PC-3 | + | + | + |
| Kidney cancer [10] | 8,160 male 4,820 female |
Caki-2 | + | + | + |
+, regression of xenografts observed; ND, not determined