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Summary of metabolic phenotypes of tissue-specific gene knockout mouse models discussed in detail in text: ACC1, FAS, and SCD1 liver knockout (LKO) models, ACC1 adipose tissue knockout (AKO), FAS hypothalamus knockout (HKO), and SCD1 skin knockout (SKO). ACC, acetyl-CoA carboxylase; FAS, fatty acid synthase; SCD, stearoyl-CoA desaturase; HC, high carbohydrate; HF, high-fat; DI, diet-induced. Color version of figure is available online.
