Table 1.

Knockout mouse models of enzymes involved in synthesis of fatty acids and triglycerides

Protein	Knockout mouse model	Reference
ATP-citrate lyase (ACL)	Global	Beigneux et al., 2004
Acetyl-CoA carboxylase-1 (ACC1)	Global	Abu-Elheiga et al., 2005
	Liver	Mao et al., 2006; Harada et al., 2007
	Adipose, macrophages, bone marrow	Mao et al., 2009
Acetyl-CoA carboxylase-2 (ACC2)	Global	Abu-Elheiga et al., 2001; Abu-Elheiga et al., 2003; Oh et al., 2005; Choi et al., 2007
Fatty acid synthase (FAS)	Global	Chirala et al., 2003
	Liver	Chakravarthy et al., 2005
	Hypothalamus, β-cells	Chakravarthy et al., 2007; 2009
Elongase 6 (ELOVL6)	Global	Matsuzaka et al., 2007
Stearoyl-CoA desaturase-1 (SCD1)	Global	Miyazaki et al., 2001; Ntambi et al., 2004
	Liver	Miyazaki et al., 2007
	Skin	Sampath et al., 2009
Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT1)	Global	Smith et al., 2000; Shih et al., 2009
Acyl-CoA:diacylglycerol acyltransferase-2 (DGAT2)	Global	Stone et al., 2004
Acyl-CoA:glycerol-3- phosphate acyltransferase- 1 (GPAT1)	Global	Hammond et al., 2002; Hammond et al., 2005; Neschen et al., 2005
Acyl-CoA:glycerol-3- phosphate acyltransferase- 4 (GPAT4)	Global	Vergnes et al., 2006; Nagle et al., 2008
1-acylglycerol-3-phosphate acyltransferase-2 (AGPAT2)	Global	Cortes et al., 2009