Table 1.
Liposome Diameter and Zeta-Potential of NTA-Containing Liposomes with 3, 1 or 0.3% NTA and 5 mol % mPEG or 1% NTA without mPEG. Control liposomes contained 1.5 mol % POPG to mimic the charge of 0.3% NTA-containing liposomes. (n=3)
3% NTA, 5% mPEG | 1% NTA, 5% mPEG | 1% NTA, 0% mPEG | 0.3% NTA, 5% mPEG | |
---|---|---|---|---|
tris-NTA-DAP | ||||
Diameter (nm) | 88.0 ± 6.4 | 82.1 ± 2.5 | 88.3 ± 6.6 | 95.2 ± 15.1 |
ζ potential (mV) | −21.0 | −18.3 ± 2.7 | −18.6 ± 1.3 | −19.3 |
tris-NTA-LYS | ||||
Diameter (nm) | 107.9 ± 3.8 | 96.0 ± 11.5 | 96.6 ± 12.1 | 82.9 ± 7.6 |
ζ potential (mV) | −22.8 | −18.6 ± 0.2 | −20.1 | −15.3 |
| ||||
NTA-DOGS | ||||
Diameter (nm) | 78.7 ± 14.7 | 75.4 ± 12.3 | 85.0 ± 7.8 | 71.5 ± 1.0 |
ζ potential (mV) | −18.9 | −16.9 ± 0.6 | −16.1 | −12.6 |
| ||||
Control (1.5% POPG, 5% mPEG) | ||||
Diameter (nm) | 80.5 ± 6.5 | |||
ζ potential (mV) | −15.6 ± 1.6 |