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. Author manuscript; available in PMC: 2011 Jun 1.

Published in final edited form as: Hum Immunol. 2010 Mar 11;71(6):566–576. doi: 10.1016/j.humimm.2010.02.008

1×10⁵ recipient responder PBMC were stimulated with 1×10⁵ donor or third party irradiated PBMC and standard 16-hr ³H-thymidine incorporation assays were performed after 7 days (peak proliferation). The stimulation indices (mean of triplicate cultures) categorized individual DBMC recipients into one of three patterns (A, B & C) of reactivity to the donor (left). On the right the mean ± SD responses to the donor and third party of the group are shown. In Fig. 1D, the SIs. of the three groups of patients are compared at 49–134 months post-transplant. SI. of 3 was considered the cut-off value for a positive response [11], represented by the dashed lines and the percentage of recipients showing unresponsiveness long-term are shown at the bottom. Please note that the data are shown in log-10 scale in Fig. 1D.

1×10⁵ recipient responder PBMC were stimulated with 1×10⁵ donor or third party irradiated PBMC and standard 16-hr ³H-thymidine incorporation assays were performed after 7 days (peak proliferation). The stimulation indices (mean of triplicate cultures) categorized individual DBMC recipients into one of three patterns (A, B & C) of reactivity to the donor (left). On the right the mean ± SD responses to the donor and third party of the group are shown. In Fig. 1D, the SIs. of the three groups of patients are compared at 49–134 months post-transplant. SI. of 3 was considered the cut-off value for a positive response [11], represented by the dashed lines and the percentage of recipients showing unresponsiveness long-term are shown at the bottom. Please note that the data are shown in log-10 scale in Fig. 1D.