Injection of the AT1-receptor antagonist losartan decreased the drinking response to AngII in a dose-dependent manner. Non-cumulative intakes by rats given various doses of losartan, administered by icv injection 20 min before 100 ng AngII, are shown in panel A (*p<0.001, †p<0.01, n=4 per group). The effects of losartan on intake were most prominent during the first 5 min of testing, when most water consumption occurred (bars with different letters differed from each other statistically, p<0.05; panel B).