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. 2010 Jun;51(6):2835–2842. doi: 10.1167/iovs.09-4755

Figure 1.

Figure 1.

VEGF expression after in vitro treatment with bevacizumab. (A) Human uveal melanoma cell lines and HUVECs expressed from 150 to 500 pg/mL VEGF, with a significant decrease after treatment with 10 or 100 μg/mL bevacizumab. (B) Human uveal melanoma cells co-cultured with HUVECs expressed higher levels of VEGF (1750–3000 pg/mL) than did individually cultured cells, which significantly decreased after treatment with 10 or 100 μg/mL bevacizumab. (C) Mouse B16LS9 melanoma cells expressed VEGF, which was significantly decreased after treatment with 10 or 100 μg/mL bevacizumab. Mouse B16LS9 melanoma cells co-cultured with mouse vascular endothelium expressed higher levels of VEGF did individually cultured cells, with a significant decrease in VEGF expression after treatment with 10 or 100 μg/mL bevacizumab.