Table 3.
Risk associated with statin type both in men and in women for non-significant and marginal outcomes
| Outcomes | Adjusted hazard ratio (95% CI) | |
|---|---|---|
| Women | Men | |
| Rheumatoid arthritis: | ||
| No statin | 1.00 | 1.00 |
| Simvastatin | 0.96 (0.84 to 1.09) | 1.12 (0.96 to 1.32) |
| Atorvastatin | 0.97 (0.81 to 1.17) | 1.06 (0.84 to 1.34) |
| Fluvastatin | 1.00 (0.52 to 1.93) | 1.07 (0.48 to 2.39) |
| Pravastatin | 0.78 (0.49 to 1.26) | 1.13 (0.68 to 1.88) |
| Rosuvastatin | 0.84 (0.44 to 1.61) | 0.72 (0.27 to 1.92) |
| Parkinson’s disease: | ||
| No statin | 1.00 | 1.00 |
| Simvastatin | 0.84 (0.71 to 1.00) | 0.85 (0.74 to 0.98) |
| Atorvastatin | 0.79 (0.61 to 1.01) | 0.89 (0.73 to 1.08) |
| Fluvastatin | 1.59 (0.87 to 2.89) | 0.47 (0.21 to 1.06) |
| Pravastatin | 0.89 (0.52 to 1.51) | 0.73 (0.47 to 1.15) |
| Rosuvastatin | 1.05 (0.50 to 2.20) | 0.73 (0.35 to 1.54) |
| Venous thromboembolism: | ||
| No statin | 1.00 | 1.00 |
| Simvastatin | 0.91 (0.83 to 0.99) | 0.88 (0.80 to 0.97) |
| Atorvastatin | 0.86 (0.76 to 0.99) | 0.86 (0.75 to 0.97) |
| Fluvastatin | 0.68 (0.41 to 1.13) | 1.04 (0.70 to 1.54) |
| Pravastatin | 1.05 (0.80 to 1.38) | 1.00 (0.76 to 1.31) |
| Rosuvastatin | 0.61 (0.36 to 1.03) | 0.53 (0.29 to 0.95) |
| Dementia: | ||
| No statin | 1.00 | 1.00 |
| Simvastatin | 0.88 (0.81 to 0.96) | 0.92 (0.83 to 1.02) |
| Atorvastatin | 0.84 (0.74 to 0.96) | 0.86 (0.74 to 1.00) |
| Fluvastatin | 0.96 (0.65 to 1.42) | 0.83 (0.53 to 1.30) |
| Pravastatin | 0.90 (0.68 to 1.18) | 1.23 (0.94 to 1.60) |
| Rosuvastatin | 0.66 (0.40 to 1.08) | 0.74 (0.42 to 1.31) |
| Osteoporotic fracture: | ||
| No statin | 1.00 | 1.00 |
| Simvastatin | 0.98 (0.92 to 1.05) | 0.97 (0.87 to 1.08) |
| Atorvastatin | 0.95 (0.87 to 1.04) | 1.07 (0.93 to 1.24) |
| Fluvastatin | 0.78 (0.57 to 1.08) | 0.74 (0.44 to 1.26) |
| Pravastatin | 0.91 (0.75 to 1.11) | 1.00 (0.73 to 1.36) |
| Rosuvastatin | 0.89 (0.65 to 1.21) | 0.68 (0.36 to 1.26) |
| Gastric cancer: | ||
| No statin | 1.00 | 1.00 |
| Simvastatin | 0.79 (0.55 to 1.13) | 0.83 (0.65 to 1.04) |
| Atorvastatin | 0.92 (0.57 to 1.49) | 0.75 (0.53 to 1.06) |
| Fluvastatin | 1.31 (0.32 to 5.28) | 0.90 (0.33 to 2.41) |
| Pravastatin | 0.85 (0.27 to 2.66) | 0.65 (0.29 to 1.46) |
| Rosuvastatin | 1.25 (0.31 to 5.05) | 1.40 (0.58 to 3.39) |
| Colon cancer: | ||
| No statin | 1.00 | 1.00 |
| Simvastatin | 0.89 (0.76 to 1.05) | 1.02 (0.90 to 1.17) |
| Atorvastatin | 0.85 (0.68 to 1.06) | 0.90 (0.74 to 1.09) |
| Fluvastatin | 0.25 (0.06 to 1.00) | 1.14 (0.66 to 1.97) |
| Pravastatin | 0.79 (0.46 to 1.34) | 0.49 (0.28 to 0.86) |
| Rosuvastatin | 1.03 (0.51 to 2.08) | 2.04 (1.29 to 3.21) |
| Renal cancer: | ||
| No statin | 1.00 | 1.00 |
| Simvastatin | 1.07 (0.86 to 1.32) | 1.10 (0.97 to 1.26) |
| Atorvastatin | 1.15 (0.86 to 1.54) | 1.10 (0.91 to 1.32) |
| Fluvastatin | 1.15 (0.43 to 3.07) | 0.54 (0.24 to 1.21) |
| Pravastatin | 0.99 (0.49 to 1.99) | 1.02 (0.68 to 1.53) |
| Rosuvastatin | 1.39 (0.58 to 3.37) | 0.78 (0.37 to 1.65) |
| Lung cancer: | ||
| No statin | 1.00 | 1.00 |
| Simvastatin | 1.10 (0.96 to 1.25) | 1.11 (1.01 to 1.23) |
| Atorvastatin | 0.88 (0.72 to 1.09) | 0.95 (0.82 to 1.10) |
| Fluvastatin | 0.13 (0.02 to 0.95) | 0.81 (0.48 to 1.38) |
| Pravastatin | 0.99 (0.64 to 1.54) | 1.07 (0.78 to 1.46) |
| Rosuvastatin | 1.28 (0.71 to 2.32) | 0.83 (0.47 to 1.46) |
| Melanoma: | ||
| No statin | 1.00 | 1.00 |
| Simvastatin | 1.02 (0.79 to 1.32) | 1.11 (0.88 to 1.40) |
| Atorvastatin | 0.94 (0.64 to 1.37) | 1.20 (0.87 to 1.66) |
| Fluvastatin | Insufficient data | 1.59 (0.66 to 3.85) |
| Pravastatin | 0.18 (0.02 to 1.27) | 1.74 (0.98 to 3.10) |
| Rosuvastatin | 0.79 (0.20 to 3.18) | 1.12 (0.36 to 3.49) |
| Breast cancer: | ||
| No statin | 1.00 | 1.00 |
| Simvastatin | 1.09 (1.00 to 1.18) | NA |
| Atorvastatin | 1.01 (0.90 to 1.14) | NA |
| Fluvastatin | 0.74 (0.45 to 1.21) | NA |
| Pravastatin | 0.93 (0.70 to 1.23) | NA |
| Rosuvastatin | 0.75 (0.47 to 1.19) | NA |
| Prostate cancer: | ||
| No statin | 1.00 | 1.00 |
| Simvastatin | NA | 1.05 (0.98 to 1.13) |
| Atorvastatin | NA | 0.99 (0.89 to 1.10) |
| Fluvastatin | NA | 1.05 (0.77 to 1.44) |
| Pravastatin | NA | 0.85 (0.67 to 1.08) |
| Rosuvastatin | NA | 0.97 (0.67 to 1.40) |
See web extra for variables that were adjusted for in hazard ratios. NA=not applicable.