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Classes of Transposable Elements (TEs). A Class I element (clade LINE-1) consist of a 5’-UTR with internal promoter activity, and two Open Reading Frames (ORFs). ORF1 encodes a nucleic acid binding protein, and ORF2 encodes a protein with Endonuclease (EN) and Reverse Transcriptase (RT) activity, lacks Long Terminal Repeats (LTR), and ends in a poly(A) tail (reviewed in [51]). Class II elements consist of a transposase gene flanked by Terminal Inverted Repeats (TIRs).
