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. 2010 Apr 28;53(10):3927–3936. doi: 10.1021/jm9016366

Scheme 1. General Synthetic Scheme.

Scheme 1

Reagents and conditions: (i) demethylation: BBr3, CH2Cl2; (ii) alkylation of phenol using alkyl halides; (iii) alkylation of phenol via Mitsunobu reaction.