Table 3. S. aureus MICs and Cell Division Inhibitory Activity for a Set of 5-Substituted Benzothiazoles.
| compd | R3 group |
S. aureus MIC (μg/mL) |
cell division inhibitiona (μg/mL) |
|---|---|---|---|
| 6g | 5-H | 2 | 4 |
| 8j | 5-Cl | 0.25 | 0.25 |
| 8f | 5-Me | 4 | 8 |
| 11 | 5-propyl | 0.125 | 0.125 |
| 8h | 5-MeO | 2 | 2 |
| 8b | 5-EtO | 0.125 | 0.125 |
| 8a | 5-Ph | 0.25 | 0.5 |
| 8d | 5-Br | 0.125 | 0.25 |
| 8e | 5-CF3 | 0.25 | 0.5 |
| 18 | 5-OH | 32 | 64 |
| 9 | 5-NH2 | >64 | WT |
| 8g | 5-(dimethylamino) | >64 | WT |
| 16 | 5-CONH2 | >64 | WT |
| 14 | 5-COOH | >64 | WT |
| 8i | 5-COOMe | 1 | 2 |
| 17 | 5-(1,2,4-oxadiazol-5-yl) | 0.5 | 0.5 |
| 13 | 5-(imidazol-2-yl) | >64 | WT |
a
Lowest concentration at which ballooning of S. aureus is observed indicating on-target activity. WT: no effect on morphology.