Table 2.
Chromosome 15 association results for selected SNPs, sorted by chromosomal position. Odds ratios are for each copy of the non-reference allele.
| Snp | AA sample | EA sample | Full sample | Cross-population heterogeneity p-value | |||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | ||
| rs17483548 | 1.58(0.95–2.61) | 7.98E-2 | 1.36(1.19–1.54) | 5.95E-6 | 1.36(1.20–1.54) | 1.88E-6 | 6.17E-01 |
| rs17405217 | 1.78(1.04–3.04) | 3.45E-2 | 1.35(1.18–1.54) | 7.50E-6 | 1.37(1.20–1.55) | 1.55E-6 | 3.56E-01 |
| rs2656052 | 0.97(0.78–1.20) | 7.90E-1 | 1.27(1.11–1.44) | 3.84E-4 | 1.18(1.06–1.32) | 3.05E-3 | 5.38E-02 |
| rs17484235 | 1.79(1.05–3.05) | 3.36E-2 | 1.36(1.19–1.54) | 5.25E-6 | 1.37(1.21–1.55) | 1.06E-6 | 3.62E-01 |
| rs7164594 | 1.00(0.80–1.25) | 9.79E-1 | 0.74(0.64–0.86) | 1.10E-4 | 0.81(0.71–0.91) | 1.04E-3 | 3.35E-02 |
| rs8034191 | 1.32(0.96–1.80) | 8.84E-2 | 1.37(1.20–1.56) | 2.30E-6 | 1.36(1.21–1.53) | 5.59E-7 | 8.47E-01 |
| rs10519203 | 1.13(0.88–1.44) | 3.45E-1 | 1.33(1.17–1.51) | 1.62E-5 | 1.29(1.15–1.44) | 1.65E-5 | 2.98E-01 |
| rs2036534 | 0.89(0.69–1.15) | 3.88E-1 | 0.75(0.64–0.87) | 2.77E-4 | 0.79(0.69–0.89) | 3.40E-4 | 2.56E-01 |
| rs12916483 | 0.86(0.64–1.15) | 3.16E-1 | 0.94(0.83–1.06) | 3.57E-1 | 0.93(0.83–1.04) | 2.11E-1 | 5.15E-01 |
| rs3813570 | 0.82(0.64–1.04) | 1.09E-1 | 0.75(0.64–0.87) | 2.35E-4 | 0.77(0.68–0.87) | 7.39E-5 | 5.36E-01 |
| rs11858230 | 0.86(0.67–1.10) | 2.37E-1 | 0.93(0.82–1.05) | 2.65E-1 | 0.92(0.82–1.02) | 1.30E-1 | 5.37E-01 |
| rs2036527 | 1.36(1.04–1.78) | 2.37E-2 | 1.37(1.21–1.56) | 1.81E-6 | 1.37(1.22–1.53) | 1.41E-7 | 9.57E-01 |
| rs667282 | 0.90(0.71–1.14) | 3.99E-1 | 0.75(0.64–0.87) | 1.68E-4 | 0.79(0.69–0.89) | 2.03E-4 | 2.28E-01 |
| rs588765 | 0.80(0.63–1.00) | 5.48E-2 | 0.91(0.80–1.02) | 1.18E-1 | 0.88(0.79–0.98) | 2.56E-2 | 3.56E-01 |
| rs6495306 | 0.80(0.63–1.00) | 5.29E-2 | 0.90(0.80–1.02) | 1.16E-1 | 0.88(0.79–0.98) | 2.44E-2 | 3.45E-01 |
| rs17486278 | 1.28(1.01–1.63) | 4.43E-2 | 1.40(1.23–1.59) | 5.74E-7 | 1.37(1.22–1.54) | 6.77E-8 | 6.12E-01 |
| rs601079 | 0.86(0.69–1.06) | 1.61E-1 | 0.90(0.79–1.02) | 1.03E-1 | 0.89(0.80–0.99) | 3.56E-2 | 6.65E-01 |
| rs680244 | 0.87(0.70–1.08) | 2.08E-1 | 0.90(0.79–1.01) | 8.68E-2 | 0.89(0.80–0.99) | 3.66E-2 | 8.03E-01 |
| rs637137 | 0.91(0.71–1.15) | 4.31E-1 | 0.74(0.64–0.86) | 1.03E-4 | 0.78(0.69–0.88) | 1.64E-4 | 1.76E-01 |
| rs951266 | 1.45(1.01–2.06) | 4.15E-2 | 1.39(1.22–1.57) | 9.83E-7 | 1.39(1.23–1.57) | 1.25E-7 | 8.29E-01 |
| rs555018 | 0.79(0.63–0.99) | 4.50E-2 | 0.91(0.80–1.02) | 1.22E-1 | 0.88(0.79–0.98) | 2.43E-2 | 3.30E-01 |
| rs647041 | 0.80(0.64–1.01) | 6.74E-2 | 0.91(0.80–1.02) | 1.27E-1 | 0.89(0.79–0.98) | 3.15E-2 | 4.04E-01 |
| rs16969968 | 2.04(1.15–3.62) | 1.47E-2 | 1.40(1.23–1.59) | 4.14E-7 | 1.42(1.25–1.61) | 4.49E-8 | 2.37E-01 |
| rs660652 | 0.80(0.63–1.00) | 5.85E-2 | 0.95(0.83–1.08) | 4.49E-1 | 0.92(0.82–1.02) | 1.37E-1 | 2.27E-01 |
| rs578776 | 1.01(0.80–1.26) | 9.58E-1 | 0.72(0.62–0.82) | 3.21E-6 | 0.79(0.70–0.88) | 7.09E-5 | 1.26E-02 |
| rs6495307 | 0.86(0.69–1.08) | 2.06E-1 | 0.91(0.81–1.03) | 1.62E-1 | 0.90(0.81–1.00) | 7.22E-2 | 6.86E-01 |
| rs1051730 | 1.38(0.98–1.95) | 6.76E-2 | 1.40(1.23–1.59) | 5.88E-7 | 1.39(1.23–1.57) | 1.16E-7 | 9.39E-01 |
| rs3743078 | 1.05(0.84–1.30) | 6.82E-1 | 0.76(0.65–0.87) | 2.68E-4 | 0.84(0.74–0.94) | 4.48E-3 | 1.82E-02 |
| rs3743077 | 0.80(0.59–1.06) | 1.28E-1 | 0.91(0.80–1.02) | 1.20E-1 | 0.89(0.79–0.99) | 3.97E-2 | 3.42E-01 |
| rs1317286 | 1.27(0.98–1.63) | 6.56E-2 | 1.36(1.19–1.54) | 4.44E-6 | 1.33(1.19–1.49) | 1.10E-6 | 5.91E-01 |
| rs938682 | 0.90(0.71–1.15) | 4.07E-1 | 0.76(0.65–0.87) | 2.87E-4 | 0.79(0.70–0.89) | 3.20E-4 | 2.59E-01 |
| rs11637630 | 0.91(0.71–1.15) | 4.22E-1 | 0.75(0.65–0.87) | 2.10E-4 | 0.79(0.70–0.89) | 2.90E-4 | 2.12E-01 |
| GSC3_26 | 0.73(0.29–1.84) | 5.07E-1 | 0.77(0.59–0.99) | 4.69E-2 | 0.76(0.59–0.97) | 3.17E-2 | 7.94E-01 |
| rs7177514 | 0.97(0.76–1.23) | 7.87E-1 | 0.76(0.65–0.88) | 3.10E-4 | 0.81(0.71–0.92) | 1.21E-3 | 9.29E-02 |
| rs6495308 | 0.98(0.77–1.25) | 8.82E-1 | 0.76(0.65–0.87) | 2.64E-4 | 0.81(0.71–0.92) | 1.34E-3 | 7.01E-02 |
| rs8042059 | 1.00(0.78–1.28) | 9.94E-1 | 0.76(0.65–0.88) | 3.23E-4 | 0.82(0.72–0.92) | 2.01E-3 | 5.70E-02 |
| rs8042374 | 1.01(0.79–1.29) | 9.15E-1 | 0.77(0.66–0.89) | 5.21E-4 | 0.83(0.73–0.93) | 3.33E-3 | 5.55E-02 |
| rs4887069 | 1.01(0.79–1.29) | 9.31E-1 | 0.76(0.65–0.87) | 2.40E-4 | 0.82(0.72–0.92) | 1.83E-3 | 4.36E-02 |
| rs8192479 | 0.54(0.03–8.65) | 6.62E-1 | 1.31(0.84–2.03) | 2.40E-1 | 1.27(0.82–1.97) | 2.79E-1 | 5.16E-01 |
| rs6495309 | 0.94(0.72–1.21) | 6.13E-1 | 0.75(0.64–0.87) | 2.67E-4 | 0.79(0.70–0.90) | 5.41E-4 | 1.67E-01 |
| rs12914008 | 0.53(0.13–2.12) | 3.67E-1 | 0.73(0.54–0.97) | 3.53E-2 | 0.71(0.53–0.95) | 2.21E-2 | 5.39E-01 |
| rs17487223 | 1.59(1.07–2.36) | 2.07E-2 | 1.35(1.19–1.54) | 3.92E-6 | 1.37(1.21–1.54) | 3.58E-7 | 4.66E-01 |
| rs1996371 | 1.10(0.72–1.69) | 6.55E-1 | 1.15(1.01–1.30) | 3.46E-2 | 1.14(1.01–1.28) | 3.95E-2 | 6.81E-01 |
Boldface denotes SNPs discussed in the text