Table 3.
Accuracy of the association parameter as ln odds of being affected given two copies of the disease allele versus no copies for a sample size of 1,000 individuals
| Nuclear | Extended | ||||
|---|---|---|---|---|---|
| Model* | RAND | ASC | RAND | ASC | |
| FP-FP | Est | 5.058 | 4.958 | 5.022 | 5.122 |
| rMSE | 0.2936 | 0.3936 | 0.3295 | 0.2296 | |
| FP-P | Est | 5.074 | 5.018 | 5.034 | 5.048 |
| rMSE | 0.2777 | 0.3336 | 0.3176 | 0.3036 | |
| P-FP | Est | 5.560 | 5.310 | 5.526 | 5.444 |
| rMSE | 0.1010 | 0.5696 | 0.3536 | 0.4357 | |
| P-P | Est | 5.560 | 5.296 | 5.536 | 5.448 |
| rMSE | 0.3195 | 0.5836 | 0.3437 | 0.4316 | |
* Model indicates the variance components that were simulated followed by those included in the analysis model (F = familial and P = polygenic); Est is the average estimate across all replicates of that model; rMSE is the square root of the mean square error; ASC represents the analysis of an ascertained sample using ascertainment correction and RAND represents the analysis of a random sample without any such correction.