Table 3.
Motor and shock response-behavior of 4-, 13-, and 24-month-old gondally-intact (intact), gonadectomized (GDX), or GDX and T-replaced (GDX + T; Experiment 1), intact or intact and T-administered (Experiment 2), and intact or intact and 3α-diol administered (Experiment 3) rats in the forced swim (struggling and swimming duration) and defensive freezing (Flinch/jump, latency to shock, duration burying) tasks.
| Condition | Forced swim test | Defensive freezing task | ||||
|---|---|---|---|---|---|---|
| Age | Steroid condition | Struggling duration | Swimming duration | Flinch/jump | Latency to shock | Duration burying |
| EXPERIMENT 1 | ||||||
| 4 Months | Intact | 167.5 ± 9.6* | 259.6 ± 17.1* | 2.0 ± 0.3 | 216.7 ± 69.3 | 141.3 ± 38.1 |
| GDX | 100.9 ± 12.8* | 161.7 ± 11.8*^ | 2.0 ± 0.3 | 232.8 ± 84.9 | 57.4 ± 19.3 | |
| GDX + T | 168.1 ± 21.1* | 266.9 ± 16.9* | 1.8 ± 0.4 | 94.5 ± 73.3 | 82.7 ± 25.9 | |
| 13 Months | Intact | 105.1 ± 14.6 | 167.8 ± 22.5 | 1.8 ± 0.2 | 80.4 ± 17.8 | 78.6 ± 28.4 |
| GDX | 106.1 ± 7.8 | 145.1 ± 13.3^ | 1.8 ± 0.3 | 146.1 ± 39.8 | 130.9 ± 60.0 | |
| GDX + T | 124.1 ± 14.5 | 209.2 ± 17.9 | 1.8 ± 0.3 | 210.0 ± 79.4 | 53.0 ± 23.8 | |
| 24 Months | Intact | 98.3 ± 10.3 | 150.4 ± 17.1 | 1.5 ± 0.3 | 223.6 ± 92.4 | 79.3 ± 33.0 |
| GDX | 115.4 ± 12.1 | 154.3 ± 15.2 | 2.6 ± 0.3 | 167.7 ± 83.7 | 123.7 ± 50.7 | |
| GDX + T | 85.5 ± 9.6 | 179.3 ± 14.2 | 2.3 ± 0.3 | 116.2 ± 43.2 | 109.3 ± 33.2 | |
| EXPERIMENT 2 | ||||||
| 4 Months | Intact | 139.7 ± 32.8 | 151.7 ± 65.1 | 1.7 ± 0.3 | 100.0 ± 55.9 | 153.0 ± 153.0 |
| Intact + T | 193.3 ± 31.4 | 251.0 ± 15.6^ | 2.0 ± 0.4 | 104.3 ± 37.3 | 56.3 ± 32.4 | |
| 13 Months | Intact | 147.3 ± 49.9 | 141.7 ± 21.6 | 2.0 ± 0.0 | 101.7 ± 85.7 | 0.0 ± 0.0 |
| Intact + T | 141.0 ± 46.1 | 242.5 ± 32.8^ | 2.3 ± 0.3 | 109.7 ± 53.9 | 167.3 ± 91.9 | |
| 24 Months | Intact | 110.0 ± 23.0 | 103.5 ± 32.5 | 2.5 ± 0.5 | 146.0 ± 85.0 | 0.0 ± 0.0 |
| Intact + T | 83.0 ± 11.1 | 77.3 ± 9.4^ | 1.7 ± 0.3 | 87.3 ± 46.5 | 37.0 ± 37.0 | |
| EXPERIMENT 3 | ||||||
| 4 Months | Intact | 125.4 ± 18.5 | 205.8 ± 20.3 | 1.8 ± 0.3 | 103.1 ± 24.7 | 125.8 ± 56.2 |
| Intact + 3α-diol | 137.0 ± 16.7^ | 209.0 ± 16.7 | 1.7 ± 0.2 | 74.7 ± 21.0 | 152.3 ± 43.7 | |
| 13 Months | Intact | 86.8 ± 9.2 | 208.9 ± 26.3 | 2.3 ± 0.1 | 127.8 ± 24.3 | 107.9 ± 40.0 |
| Intact + 3α-diol | 146.9 ± 17.1^ | 273.8 ± 34.9 | 1.8 ± 0.1 | 96.8 ± 18.9 | 96.5 ± 40.6 | |
| 24 Months | Intact | 51.1 ± 14.8 | 196.9 ± 28.5 | 1.9 ± 0.2 | 111.6 ± 26.5 | 33.4 ± 14.8 |
| Intact + 3α-diol | 122.4 ± 23.7^ | 223.9 ± 32.8 | 1.6 ± 0.3 | 91.1 ± 34.7 | 293.5 ± 81.8 | |
*Denotes significant difference from 13- and 24-month-old rats (p < 0.05). ^Denotes significant difference from intact or intact + vehicle groups (p < 0.05).