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. 2010 Feb 5;2:1. doi: 10.3389/neuro.24.001.2010

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Copyright © 2010 Potier, Turpin, Sinet, Rouaud, Mothet, Videau, Epelbaum, Dutar and Billard.

This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.

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Spatial learning and hippocampal synaptic plasticity are impaired in aged rats. (A, left) Comparison of the distance swum before escaping onto the hidden platform over 6 days of training in adult and aged rats (##p < 0.01, repeated measures ANOVA). (A, right) Comparison of time spent by rats swimming through the different quadrants, including quadrant 4, where the platform was situated during place learning, registered over a 90-s probe trial (#p < 0.05, unpaired t-test). (B, left) Time-course of LTP induction in adult and aged rats by HFS (arrow). (B, right) Comparison of mean LTP magnitude (±SEM) calculated for the last 15 min of recording. (C, left) Time course of depotentiation of previously HFS-potentiated synaptic responses induced in adult and aged rats by LFS. (C, right) Comparison of depotentiation magnitude (±SEM) calculated for the last 15 min of recording. (D) Illustration of results obtained with TBS protocols. (#p < 0.05, ##p < 0.01, unpaired t-test).