Table 4.

C-arylation of diethyl malonate using different aryl halides^a.

Entry	Aryl halide	Product	Time (h)	Yieldb (%)
1	iodobenzene	2-phenylmalonic acid diethylester	9	78
2	bromobenzene	2-phenylmalonic acid diethylester	11	76
3	p-nitroiodobenzene	2-(4-nitrophenyl)-malonic acid diethylester	6	81
4	p-methyliodobenzene	2-p-tolylmalonic acid diethylester	12	76
5	m-trifluoromethyliodobenzene	2-(3-trifluromethyl-phenyl)-malonic acid diethylester	7	80
6	1-iodo-2-methylbenzene	2-o-tolylmalonic acid diethylester	13	75
7	1-iodo-4-methoxybenzene	3-(4-methoxy-phenyl)-malonic acid diethylether	14	74

^aReaction conditions: diethyl malonate (3 mmol), aryl halide (1 mmol), 10 mol % CuO-nanoparticles, Cs₂CO₃ (0.5 mmol), DMSO; temperature 80 °C; N₂; 1 atm.

^bIsolated and optimized yields.