Changes in pulse oximetry during rest and exercise in all experiments. The ordinate displays arterial saturation as measured by pulse oximetry in percent (SpO2) and the abscissa displays Naughton work stages. The insert indicates the studies performed with room air (RA), O2 at flows of 2 L/min (2LO2), and devices 1 through 4 (D1–D4). The data points are mean values and the brackets indicate 1 SEM. The zero values represent resting observations. A, B, and C depict the experiments performed at regulator settings of 2, 5, and continuous, respectively.