Fig. 6.

Green nodes are metabolites identified in the dataset. Purple nodes are the ones inferred by our gap filling method. Square nodes are reactions nodes, when the border is red it means that the reaction can occur in both directions. This pathway is part of amino acids degradation. The sub-network reported here was produced from the current version of Trypanocyc. It is notable that this version has not benefited from expert pruning so the reactions catalysed by spermine synthase and spermidine dehydrogenase have not been reported in T. brucei. Furthermore the reaction catalysed by trypanothione reductase, usually converts the oxidised form of trypanothione to its reduced form, which is then involved in multiple cellular reductions prior to its being enzymatically reconverted to the reduced form