Fig. 5.

Electrophysiological recordings of LTP. (a) Normalized field EPSP amplitude recorded during 10 min before and 60 min after tetanus (100 Hz, 1 sec) for placebo (n = 10 slices), clozapine 3 mg/kg/day (n = 16 slices) and clozapine 10mg/kg/day (n = 6 slices) STOP null mice. (b) Normalized field EPSP amplitudes between 30 and 40 min after tetanus. In wild type mice, LTP values were similar in all studied groups (untreated, placebo and clozapine-treated) and the value for WT placebo group is shown for comparisons; STOP-null mice treated with placebo present an impairment of LTP when compared to their WT littermates [**: p<0.01, KO vs WT placebo]. Only the dose of 10 mg/kg/day of clozapine significantly improved LTP of chronically-treated mice [#: p<0.05 between KO groups, with A different from C, p<0.05]