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. Author manuscript; available in PMC: 2010 May 21.
Published in final edited form as: Clin Cancer Res. 2009 Feb 24;15(5):1635–1644. doi: 10.1158/1078-0432.CCR-08-1905

Fig. 1. Inhibition of cPLA2 with AACOCF3 enhances cell death and prevents activation of pro-survival signaling in irradiated vascular endothelial cells.

Fig. 1

Clonogenic Survival. (A, B) 3B11, LLC, and H460 cells were plated and treated with 1 μM AACOCF3 for 30 min prior to irradiation. After 1 week, colonies consisting of ≥ 50 cells were counted and normalized for plating efficiency. A) Shown are average surviving fractions and SEM from three experiments; * p < 0.05. B) Shown is a bar graph of percent survival after exposure to 2 Gy; * p < 0.05. ERK phosphorylation. C) 3B11, LLC, and H460 cells were treated with 1 μM AACOCF3 for 30 min prior to irradiation with 3 Gy and lysed 3 min after the beginning of irradiation. Shown are the Western blot analyses with specific antibodies to phospho-ERK1/2, total ERK1/2, and actin.