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. Author manuscript; available in PMC: 2010 May 21.
Published in final edited form as: Clin Cancer Res. 2009 Feb 24;15(5):1635–1644. doi: 10.1158/1078-0432.CCR-08-1905

Fig. 3. Inhibition of cPLA2 with AACOCF3 decreases tumor size in irradiated mouse models.

Fig. 3

Using heterotopic tumor models of Lewis Lung Carcinoma (LLC) (A, B) or H460 large cell carcinoma of the lung (C, D), mice were treated intraperitoneally with vehicle (control) or 10 mg/kg AACOCF3 and tumors were irradiated 30 minutes later with 3 Gy. Treatment was repeated for 5 consecutive days. Tumor volumes were calculated using external caliper measurements. A) Shown are the mean LLC tumor volumes in each of the treatment groups (control, IR, AACOCF3, and AACOCF3 + IR). B) LLC; Shown is a bar graph of the average number of days taken to reach 700 mm3 in comparison to control with SEM from group of 4 to 6 mice; *, p = 0.02. C) H460; Shown is a bar graph of the average tumor volumes 13 days post-injection with SEM from group of 4 to 6 mice; *, p =0.05. D) H460; Shown is a bar graph of the average number of days taken to reach 1400 mm3 in comparison to control with SEM from group of 4 to 6 mice.