Fig. 5. Treatment with AACOCF₃ results in increased apoptosis and decreased Akt phosphorylation within irradiated tumor models.

C57/BL6 mice with LLC tumors were treated as described in Fig. 4. A) TUNEL staining and hematoxylin counterstaining were performed on 5 μm sections from LLC tumors. Shown are representative micrographs of tumor with blood vessels from treated mice White arrows indicate TUNEL-positive endothelial cells; red arrows indicate TUNEL-positive tumor cells. B) Phospho-Akt immunofluorescence staining (green) and DAPI counterstaining (blue) were performed on LLC tumor sections from treated mice. Shown are representative micrographs of positive staining for Akt phosphorylation in LLC tumors.