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. Author manuscript; available in PMC: 2011 May 21.
Published in final edited form as: ACS Chem Biol. 2010 May 21;5(5):477–487. doi: 10.1021/cb900282e

Table 1.

Summary of solubilization and secretion behaviors reported for select mutant myocilins of relevance to the current study.

Mutation Glaucoma phenotype In vitro solubilization (56) Secretion from 37°C culture HEK293 (12)/HTM (13) Secretion from 30°C culture HEK293 (12)/HTM (13) ER retention (10, 19)
D380A Mild + +/− +/+ n.d.
I477S Moderate − −/n.d. +/n.d. n.d.
I477N Severe − −/− +/− +
K423E Severe − −/− −/− +

(+) Positive measurement for solubilization, secretion or ER retention, as indicated by column heading, (−) Negative measurement for respective measurements, (n.d.) measurement not determined.