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. 2010 Mar 18;59(6):1338–1348. doi: 10.2337/db09-1324

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© 2010 by the American Diabetes Association.

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FIG. 2. — Chronic rapamycin treatment coordinately downregulates genes required for triglyceride hydrolysis, fatty acid transport, and esterification in adipose tissue. Rats were treated with rapamycin as described in the legend to Fig. 1, and adipose tissue was sampled and processed as described in the research design and methods section for determinations of LPL, FATP1, FAT/CD36, Lipin1, PEPCK, MGL, HSL, ATGL, PPARγ1, and PPARγ2 mRNA expression. The graphs depict mRNA expression in the adipose tissue of target genes corrected for the expression of 36B4 as a control gene. n = 12 for each group. *P ≤ 0.05, **P ≤ 0.01.