FIG. 3.

Chronic rapamycin treatment induces glucose and insulin intolerance in rats. Rats were treated with rapamycin as described in the legend to Fig. 1 and fasted for 6 h before intraperitoneal tolerance tests. Plasma glucose (A) and insulin levels (B) were measured during a glucose tolerance test. C: Plasma glucose levels were measured during an insulin tolerance test. n = 12 for each group. Black squares: CTRL; white squares: RAP. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001.