TABLE 1.

Effect of 15-day rapamycin treatment on weight, food intake, and metabolic parameters of treated rats

	Control	Rapamycin
Body weight (g)	303.6 ± 3.68	226.3 ± 4.34***
Weight gain (g)	91.4 ± 3.57	12.8 ± 3.87***
Food intake (g)	256.4 ± 6.53	217.7 ± 8.53**
Food efficiency (body weight gain/food intake)	0.117 ± 0.004	0.019 ± 0.006***
Glucose (mmol/l)	8.5 ± 0.33	13.3 ± 2.53*
Insulin (pmol/l)	351.5 ± 58.7	1,265.1 ± 395.1*
Glucagon (ng/l)	127.25 ± 10.65	130.47 ± 14.33
Triglycerides (mmol/l)	0.644 ± 0.050	0.848 ± 0.060*
NEFAs (mmol/l)	0.115 ± 0.020	0.190 ± 0.040*
Glycerol (mg/dl)	1.025 ± 0.084	1.177 ± 0.107
Lactate (mmol/l)	0.904 ± 0.050	0.852 ± 0.039
Adiponectin (μg/ml)	11.89 ± 1.53	12.11 ± 0.83
Leptin (ng/ml)	9.48 ± 1.86	4.94 ± 1.51*

Data are average ± SE (n = 12 control, n = 10 for rapamycin). Refed plasma data are average ± SE (n = 6–12 for control, n = 6–10 for rapamycin).

*P ≤ 0.05,

**P ≤ 0.01,

***P ≤ 0.001 vs. control. NEFAs, nonesterified fatty acids.