TABLE 1.

High-fat–fed serum hormone and serum metabolite levels

	Wild type	Txnip KO	P value
Serum hormone
Insulin (pg/ml)	70.0 ± 19.4	28.3 ± 4.0	0.05
Glucagon (pg/ml)	30.4 ± 3.0	29.4 ± 5.1	0.92
Leptin (pg/ml)	611 ± 110	360 ± 52	0.03*
Adiponectin, HFD (ng/ml)	9.1 ± 4.2	4.2 ± 0.6	<0.01*
Adiponectin, SCD (ng/ml)	5.7 ± 0.9	6.8 ± 0.5	0.33
Serum metabolites
Glucose (mg/dl)	139 ± 9	87 ± 6	<0.001*
Triglycerides (mg/dl)	146 ± 32	258 ± 31	0.02*
FFA (before clamp, mEq/ml)	0.97 ± 0.07	1.33 ± 0.16	0.04*
Δ FFA (after clamp, % change)	−3.3 ± 8.9	−31.8 ± 6.2	0.02*
β-hydroxybutyrate (mmol/l)	1.57 ± 0.26	5.88 ± 0.47	<0.0001*

Unless indicated, values reflect serum levels after an overnight fast.

*Statistical significance by Student t test.