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. 2010 Mar 9;59(6):1512–1520. doi: 10.2337/db09-1456

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© 2010 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 4. — Impact of cardiac-specific IGF-1R overexpression on diabetes-induced diastolic dysfunction. A: Representative mitral flow patterns from pulsed wave Doppler echocardiography. Diabetes (B) tends to decrease E velocity and (C) increases peak A velocity, with (D) net reduction in E:A wave ratio in both Ntg and IGF-1R diabetic mice. IGF-1R (E) reduces incidence of diastolic dysfunction, (F) restores normal deceleration time, and (G) tends to improve LV end diastolic pressure. n = 7–12 in each group; *P < 0.05 vs. sham of the same genotype; †P < 0.05 vs. Ntg counterpart.