TABLE 3.
Case-control studies of obesity for six MTNR1B variants in Danish (up to n = 6,828) and French (n = 3,773) individuals
| Danish |
French |
Combined (n = 10,601) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Normal weight | Obesity | OR (95%CI) | P | Normal weight | Obesity | OR (95%CI) | P | OR (95%CI) | P | |
| G24E* | 2,365/442/17 | 3,168/678/33 | 1.21 (1.05–1.39) | 0.0081 | 2,276/353/14 | 859/159/8 | 1.21 (1.00–1.46) | 0.046 | 1.20 (1.08–1.34) | 8.3 × 10−4 |
| L60R* | 2,822/3/0 | 3,868/1/0 | 0.12 (0.01–1.4) | 0.091 | 2,708/8/0 | 1,019/4/0 | 1.29 (0.39–4.33) | 0.68 | 0.66 (0.21–2.06) | 0.48 |
| V124I* | 2,824/12/0 | 3,833/31/0 | 1.74 (0.83–3.67) | 0.14 | 2,691/3/0 | 1,016/2/0 | 1.78 (0.29–10.81) | 0.53 | 1.74 (0.91–3.35) | 0.095 |
| R138C | 2,822/6/0 | 1,906/3/0 | 0.89 (0.21–3.82) | 0.87 | ||||||
| R231H | 2,809/26/1 | 1,888/20/0 | 1.0 (0.53–1.9) | 0.99 | ||||||
| K243R | 2,647/185/2 | 1,786/124/3 | 0.99 (0.77–1.27) | 0.93 | ||||||
Data are presented as wild-type/heterozygous/homozygous unless otherwise indicated. ORs and P values were calculated assuming a dominant (L60R, V124I, R138C, R231H, and K243R) or additive (G24E) genetic model adjusted for age and sex. Nationality has been applied as an adjusting factor in the combined analyses.
*Additional obese cases (n = 1,991) were genotyped for G24E, L60R, and V124I. Normal weight was defined as BMI < 25 kg/m2. Obesity was defined as BMI ≥ 30 kg/m2.