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. Author manuscript; available in PMC: 2010 May 22.
Published in final edited form as: Curr Med Chem. 2009;16(33):4382–4398. doi: 10.2174/092986709789712871

Fig. (3). The inhibition of mitochondrial permeabilization as a pharmacological approach to limit myocardial ischemia-reperfusion injury.

Fig. (3)

Schematic representation of the pharmacological strategies which have been or might be used to limit mitochondrial membrane permeabilization. They can target directly or indirectly the outer mitochondrial membrane permeability (OMP) or both the outer and the inner membrane (mPTP).

CyP-D: cyclophilin D; mPTP: permeability transition pore; VDAC: voltage-dependent anion channel.

➔ : activation

⊥: inhibition

Inline graphic: activation or inhibition