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. Author manuscript; available in PMC: 2010 May 23.
Published in final edited form as: AIDS. 2010 Mar 13;24(5):659–667. doi: 10.1097/QAD.0b013e328336781d

Figure 2. RNase H cleavage activity of WT, K70R, Y181C, N348I, K70R/Y181C and K70R/Y181C/N348I HIV-1 RT that occurs during the AZT-MP excision reaction.

Figure 2

A) Schematic illustrating the location of the RNase H cleavage sites in the RNA template.

B) Representative autoradiogram of the RNase H cleavage activity of the WT and mutant HIV-1 RTs. Experiments were carried out as described in the Materials and Methods. The reaction times were 1, 3, 5, 10, 20, 30, 45, 60 and 90 min.