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. Author manuscript; available in PMC: 2010 May 23.
Published in final edited form as: AIDS. 2010 Mar 13;24(5):659–667. doi: 10.1097/QAD.0b013e328336781d

Figure 3. Autoradiogram of steady-state DNA synthesis by WT and mutant HIV-1 RT in the presence of AZT-TP and 3 mM ATP.

Figure 3

A) Complete autoradiogram indicating primer, final product, and AZT-MP chain-termination sites. Experiments were carried out as described in the Materials and Methods. The time points for the reactions were 15, 30, 60, 90 and 120 min.

B) Different contrast of the final product bands from the autoradiogram presented in (A). This figure highlights that the addition of N348I to K70R/Y181C HIV-1 RT compensates for the antagonism of K70R by Y181C.