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. Author manuscript; available in PMC: 2010 May 23.
Published in final edited form as: AIDS. 2010 Mar 13;24(5):659–667. doi: 10.1097/QAD.0b013e328336781d

Figure 4. ATP-mediated AZT-MP excision activities of WT and mutant HIV-1 RT on an RNA/DNA T/P.

Figure 4

A) The autoradiogram shows the AZT-MP excision reactions carried out by K70R/M184V and K70R/M184V/N348I HIV-1 RT. The reaction times were 3, 5, 10, 20, 30, 60 and 90 min. The isotherm shows ATP-mediated AZT-MP excision reactions carried out by WT, K70R, K70R/M184V and K70R/M184V/N348I HIV-1 RT. Data are the mean ± standard deviation from at least three independent experiments.

B) The autoradiogram shows the AZT-MP excision reactions carried out by K70R/L74V and K70R/L74V/N348I HIV-1 RT. The reaction times were 3, 5, 10, 20, 30, 60 and 90 min. The isotherm shows ATP-mediated AZT-MP excision reactions carried out by WT, K70R, K70R/L74V and K70R/L74V/N348I HIV-1 RT. Data are the mean ± standard deviation from at least three independent experiments.