Figure 2.
TNFR-1 and LTβR activation induces mRNAs encoding lymphorganogenic molecules. A, SMC were stimulated with TNF (T) or α-LTβR (L) or both (LT) as described in Figure 1, and microarrays were prepared after 24 hours. Heat maps (A) represent upregulated genes (left heat map) and (B) the top 20 induced genes of 1 of 3 induction patterns. C, Top 40 of interferon signature derived from www.interferome.com data bank are displayed for ease of reading. D, Induced genes in gene ontology terms. E, Downregulated genes.