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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2010 Feb 5;30(3):395–402. doi: 10.1161/ATVBAHA.109.191395

Figure 4.

Figure 4

Hyperinduction of de novo synthesis and prolonged secretion of CCL5, CX3CL1, CXCL13, and CCL19 by TNF/α-LTβR activation. SMC were stimulated with TNF, α-LTβR, or both, as described in Figure 1. At the indicated time points, chemokine levels in supernatants were determined by enzyme-linked immunosorbent assays. Data represent means of 3 or 5 (6 hours, n=3; 24 hours, n=5; 48 hours, n=5; 72 hours, n=3) independent SMC cultures±SEM. Student unpaired t test. *P<0.05. **P<0.01. ***P<0.001. Only probability values for chemokine levels with the highest values are shown for reasons of clarity. At 72 hours, in 2 experiments, SMC that received TNF CCL19 levels were below the detection limit and the CCL19 level within the detection limit is displayed for the remaining data point.

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